Juventus’ busy run of fixtures continues against Genoa on Tuesday, before they host Torino four days later.
Ronaldo has played every minute of their four games since the coronavirus-enforced break, while Dybala has started each match.
Sarri said the pair were likely ready to start again, but he knows the star duo will need a rest at some stage.
“It’s likely that they can start again [against Genoa],” he told a news conference.
“It’s clear that if they play every game, in two or three matches we may have a problem, but I don’t think there is any risk for them to suffer some sort of fatigue right now.
“In the long run though we need to have [Gonzalo] Higuain fit and able to play a large part of the game, this will become essential at some point.”
With 10 games remaining in the Serie A season, Juventus hold a four-point lead atop the table.
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